Single-Molecule Sensors and NanoSystems International Conference – S3IC 2026

Sensor systems exhibit extraordinary sensitivity for detecting physical, chemical, and biological entities at the micro/nanoscale. The detection and analysis of molecules on miniature devices with many possible applications in health, environment, analysis, and security is particularly exciting. A new class of label-free micro and nanosensors is starting to emerge, allowing us to observe dynamic processes at the single molecule level directly, with unprecedented spatial- and temporal resolution and without significantly affecting the natural and functional movements of the molecules. Micro- and nanosensors by virtue of their small interaction length probe molecules over a dynamic range often inaccessible by other techniques. Their small size enables an exceedingly high sensitivity, and the application of quantum optical measurement techniques can allow us to approach or surpass classical limits of detection. Advances in optical and electrical measurement methodology, laser interferometry, quantum optics, micro/nanofluidics, control of molecules and reactions at the nanoscale, DNA origami/synthetic molecular machines, in-vivo and wearable sensing materials, all contribute to the rapid progress of the field of Single Molecule Sensors and NanoSystems. It is this convergence of previously often disparate fields that is accelerating the advancements in micro and nano-sensing.

This conference will bring together researchers in the rapidly advancing field of Single Molecule Sensors and NanoSystems on January 19-21, 2026 in Rome. The conference focuses on the most recent advances in micro and nano-sensing techniques that have either demonstrated single-molecule detection or that can advance or contribute towards single-molecule detection capability on sensor chips in the longer term.