Eq. Perturbations Moléculaires, Cellulaires et Xénobiotiques
Professeur d’Enzymologie Université Paris Cité
Co-responsable Master Biologie Moléculaire et Cellulaire et parcours M2 BBPM
Directeur adjoint du Collège des Etudes Doctorales

After completing a PhD in the field of leukemia (IUH, Hôpital Saint-Louis, Paris), followed by a Marie Curie Fellowship at the University of Bergen (Molecular Biology Institute, Norway), Frédéric Pendino obtained a Scientist position at Inserm in 2009. His research axes encompass the fields of Onco-Immuno-Hematology and Cancer Epigenetics by using leukemia and solid tumor models. Of note, he discovered and characterized the role of the epigenetic factor RINF (also known as CXXC5) in tumor and immune cells. Lately, his group at the Cochin Institute has gained expertise in the production of CAR-T cells and developed innovative strategies to study and enhance (CAR-)T cell persistence in preclinical tumor models.

Unité de Biologie Fonctionnelle et Adaptative (BFA) – CNRS UMR 8251
Eq. Therapeutic peptides: Modulation of protein-protein interactions (TPM2PI) – Inserm ERL U1133
Professeur de BioInformatique Structurale – Université Paris Cité

Co-responsable du parcours M1 BI-IPFB du Master de BioInformatique

Gautier MOROY uses molecular modeling approaches combined with artificial intelligence-based methods to investigate the molecular mechanisms underlying the interactions between therapeutically relevant proteins and potentially inhibitory ligands (small molecules or peptides).

Jonathan Weitzman is a professor of Genetics and Epigenetics at the Université Paris Cité and the founding director of the Center for Epigenetics and Cell Fate (UMR Epigénétique et Destin Cellulaire). His lab focuses on epigenetic signaling and protein methylation events in parasite infections and cancer. Jonathan co-directs the European Masters’ in Genetics (Magistère Européen de Génétique) and the Ecole Universitaire de Recherche G.E.N.E. Graduate School.

Head of Epigenetic Chemical Biology Unit

Director of the Department of Structural Biology and Chemistry

Director of  CNRS UMR3523 Chem4Life  – Chemistry for Life Sciences

Professor of Applied Mathematics
Vice-President Valorisation and industrial partnerships
Université Paris Cité

Director of CNRS UMR7216 “Epigenetics and Cell Fate”
Head of the Epigenetic Dynamics and Cellular Differentiation Team

He is interested in the regulation of gene expression through chromatin modifications, especially lysine methylation. His team’s work aims to identify novel determinants of both normal and pathological cell fate transitions and to elucidate the underlying molecular mechanisms. For example, they revealed the critical role of chromatin architecture in shaping oncogenic programs through connections between gene expression, the epigenome, 3D genome organization, and nuclear mechanics.